Pneumolysin, PspA, and PspC contribute to pneumococcal evasion of early innate immune responses during bacteremia in mice.
نویسندگان
چکیده
The pneumococcal virulence factors include capsule, PspA, PspC, and Ply. Cytometric analysis demonstrated that the greatest levels of C3 deposition were on a Deltaply PspA(-) PspC(-) mutant. Also, Ply, PspA, and PspC expression resulted in C3 degradation in vitro and in vivo. Finally, blood clearance assays demonstrated that there was enhanced clearance of Deltaply PspA(-) PspC(-) pneumococci compared to the clearance of nonencapsulated pneumococci.
منابع مشابه
Pneumolysin, PspA, and PspC Contribute to Pneumococcal Evasion of Early Innate 1 Immune Responses during Bacteremia in Mice
= 50 words; Text = 1216 words; Black and white figures = 4; Tables = 1 21 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Infect. Immun. doi:10.1128/IAI.01727-06 IAI Accepts, published online ahead of print on 12 January 2007 on O cber 5, 2017 by gest http/iai.asm .rg/ D ow nladed fom
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ورودعنوان ژورنال:
- Infection and immunity
دوره 75 4 شماره
صفحات -
تاریخ انتشار 2007